You wouldn’t know it now, but the bacterium that causes cholera is a surprisingly flimsy organism. This scourge that kills thousands every year and has terrified many millions is actually quite easy to kill. A low dose of chlorine will do the trick. Even a little citrus juice to bring down the pH a bit will work. In fact, the acidity of the stomach will kill the vast majority of V. cholerae that a person ingests. It is far easier to kill than enteric viruses, parasites, and most bacteria.
But if you don’t kill it, cholera will not be interested in doing you the same favor. Thank god for Oral Rehydration Therapy (ORT). This simple and cheap cholera therapy composed of water, glucose, and salts has completely changed the outlook towards cholera treatment. What used to be an expensive and grueling intravenous rehydration process has been simplified so that the cost of the therapy itself is almost not an issue. If an infected person can get to a site with oral rehydration salts, that person has a very good chance of surviving.
I have been amazed recently to learn about the mechanism for ORT. I had always assumed that it was a simple replenishment of lost fluids and nutrients due to severe diarrhea. This is pretty far off. I won’t get into the details, but suffice it to say that ORT replenishes lost fluids and electrolytes through a complex mechanism that requires a significant understanding of human physiology.
Yet the beauty of ORT lies not in its hidden complexity, but in its outward simplicity. There are plenty of medications with equally intricate pathways. ORT is distinguished from these other therapies by the ease with which it can be implemented, even in the most resource poor settings. How many medical treatments can boast to have saved so many lives using such simple ingredients as water, sugar, and salts?
Unfortunately, as we all can see on the news, even something so basic as ORT can be out of reach in a place like Haiti. If we could dedicate the same brilliant scientific effort that led to the development of ORT to the development of simpler, cheaper, and more efficient water treatment strategies, we would be far better off. Rather than grapple with V. cholerae when it has already taken a hold in someone’s body, we can attack it while it is weak and susceptible to the simplest treatment methods.
I am not saying anything new. But I am frustrated to see how good medicine is at addressing an illness when it has already begun and how much more we should be doing to prevent this illness from occurring in the first place. I know first-hand that it is difficult to effectively implement a safe drinking water intervention, but I am sure we could have done more to provide clean water to Haitians months or years ago, possibly preventing the current epidemic or at least diminishing its impact.
The challenge will not be in finding ways to produce clean water—we already know how to do that very well—but in finding new ways to provide that water cheaply and in an appealing way. I hope people will take the ORT approach to address this challenge: Combining sound science with an awareness of the need for simple and cheap interventions for low-income settings.